If a nursing mom is really an extremely-quick metabolizer of codeine, it may lead to morphine overdose within the nursing newborn and trigger extremely significant Uncomfortable side effects.
A Health care professional should be consulted prior to having any drug, altering any diet program or commencing or discontinuing any study course of cure.
Promethazine hydrochloride wasn't mutagenic inside the in vitro bacterial reverse mutation assay or clastogenic while in the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.
Medical doctors commonly prescribe codeine for gentle to average ache and hydrocodone for average to intense ache. A physician will evaluate a person’s demands and decide regardless of whether to prescribe the pure type, a direct-launch or sluggish-release kind, or a mixture medication that includes An additional drug.
Drug interactions may well adjust how your remedies do the job or boost your threat for major side effects. This doc isn't going to include all achievable drug interactions.
It is soluble in h2o and freely soluble in Alcoholic beverages. The molecular body weight is 320.88. Its molecular formula is C17H20N2S•HCl, and it has the next chemical structure.
Significant, life-threatening, or deadly respiratory despair is documented with the use of opioids, which include codeine, one of several Energetic elements in Promethazine with Codeine Oral Solution. Codeine provides dose-similar respiratory melancholy by right acting over the Mind stem respiratory Middle that controls respiratory rhythm and will make irregular and periodic breathing. Codeine is matter to variability in metabolism based mostly on CYP2D6 genotype, which can lead to an elevated publicity into the Energetic metabolite morphine [see Warnings and Precautions (five.3)]. Promethazine exerts a depressant effect on the respiratory Middle that is certainly independent of and additive to that of other respiratory depressants, together with codeine [see Warnings and Precautions (five.
[16] Greater fluid ingestion and stool softeners are often encouraged to people to mitigate this unwelcome result. Nausea/vomiting is an additional prevalent adverse influence, but it surely frequently diminishes inside times to months of continued codeine exposure. Anti-emetic therapies in the two oral and rectal formulations are available for treatment.
The concomitant utilization of opioids with other medication that influence the serotonergic neurotransmitter program has resulted in serotonin syndrome.
Examine the Medication Tutorial supplied by your pharmacist Before you begin taking promethazine/phenylephrine/codeine and each time you obtain a refill. When you have any inquiries, question your medical professional or pharmacist.
These indicators may possibly indicate that you're an "extremely-fast metabolizer of codeine". Due to this fact, there is an excessive amount of morphine in the body plus much more side effects of morphine than typical. Kids could be Specially sensitive to this impact. Do not give this medicine to:
Tummy or bowel blockage (together with paralytic ileus)—Really should not be Employed in patients with these ailments.
Most MAO inhibitors should also not be taken for two months right before therapy using this medication. Question your medical doctor when to begin or stop using this medication.
The codeine and promethazine in Promethazine with Codeine Oral Option may well enhance the frequency of seizures in sufferers with seizure disorders, and should improve the hazard Promethazine codeine syrup of seizures transpiring in other scientific configurations connected with seizures.